Proliferating cells mechanism of aging

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Proliferating cells mechanism of aging

Cell cycle is a highly ordered set of biochemical events leading to the faithful duplication and segregation of eukaryotic chromosomes. This process is tightly controlled by checkpoint mechanisms evolved to prevent cells from entering any cell cycle phase before the completion of the previous one. Normal proliferating cells possess fully functional checkpoint controls and respond to treatment with cytotoxic agents, most of which are genotoxic, by cell cycle arrest in G1 and/or G2 phase.

The tumor suppressor p53 plays a pivotal role in cellular response to genotoxic damage or other forms of stress by inducing cell cycle arrest or apoptosis and thus preventing the propagation of DNA damage that may lead to malignant cell transformation. p53 is a potent transcription factor that controls the activity of multiple target genes involved in the control of cell cycle or apoptosis. One of the main functions of activated p53 is induction of the G1-S and G2-M checkpoints of the cell cycle.